Key result
Sixteen weeks of intense endurance training in male Wistar rats increased right ventricular collagen deposition and TGF-β1 expression, suggesting potential pathological structural changes and fibrosis.
Why the study?
Intense endurance exercise may cause cardiac fibrosis over the long term, but whether it leads to pathological structural changes in the rat heart required investigation.
Does intense endurance training cause pathological structural changes in the right ventricle in male Wistar rats?
Does intense endurance training cause pathological structural changes in the right ventricle in male Wistar rats?
Intense, long-term endurance exercise induces right ventricular fibrosis and alters desmosomal protein expression in a rat model, suggesting potential pathological structural changes.
Answers are grounded in this paper and cite their sources.
Animal data on intense endurance exercise and cardiac fibrosis remain preliminary; leaves open effects in humans.
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marvast et al. (2021) studied Cardiac fibrosis and right ventricle structural changes (n=16). Intense endurance training vs. Control (no training) was evaluated on Right ventricular collagen deposition (p=0.01). Sixteen weeks of intense endurance training in male Wistar rats increased right ventricular collagen deposition and TGF-β1 expression, suggesting potential pathological structural changes and fibrosis.
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