Key result
Fibrinogen level was an independent predictor of MACE (OR 7.798; 95% CI 3.44-17.676), and the derived ACEF-FIB score showed superior discrimination (AUC 0.753) compared to existing risk scores.
Why the study?
The study was conducted to explore whether incorporating fibrinogen levels could improve the predictive value of the ACEF score in patients with ACS.
Does the ACEF-FIB score improve the prediction of MACE compared to other risk scores in patients with ACS undergoing PCI?
Observational (n=290)
Does the ACEF-FIB score improve the prediction of MACE compared to other risk scores in patients with ACS undergoing PCI?
Odds Ratio: 7.798 (95% CI 3.44–17.676)
p-value: p=<0.001
The addition of fibrinogen levels to the ACEF score (ACEF-FIB) improves the prediction of MACE in patients with ACS undergoing PCI compared to traditional risk scores.
ACEF-FIB may aid MACE risk stratification in ACS-PCI; hypothesis-generating and requires prospective validation before clinical adoption.
Background: The purpose of this study was to explore whether consideration of FIB levels might improve the predictive value of the ACEF score in patients with ACS. Methods: A total of 290 patients with ACS were enrolled in this study. The clinical characteristics and MACE were recorded. Results: Multivariate logistic regression analysis revealed that the FIB level (odds ratio=7.798, 95%CI, 3.44–17.676, P<0.001) and SYNTAX score (odds ratio=1.034, 95%CI, 1.001–1.069, P=0.041) were independent predictors of MACE. On the basis of the regression coefficient for FIB, the ACEF-FIB was developed. The area under the ROC of the ACEF-FIB scoring system in predicting MACE after PCI was 0.753 (95%CI 0.688–0.817, P<0.001), a value greater than those for the ACEF score, SYNTAX score and Grace score (0.627, 0.637 and 0.570, respectively). Conclusion: ACEF-FIB had better discrimination ability than the other risk scores, according to ROC curve analysis, net reclassification improvement and integrated discrimination improvement.
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Zhao et al. (2023) conducted an observational in Acute Coronary Syndrome (n=290). Fibrinogen (FIB) level and ACEF-FIB score vs. ACEF score, SYNTAX score, and Grace score was evaluated on Major Adverse Cardiovascular Events (MACE) (OR 7.798, 95% CI 3.44-17.676, p=<0.001). Fibrinogen level was an independent predictor of MACE (OR 7.798; 95% CI 3.44-17.676), and the derived ACEF-FIB score showed superior discrimination (AUC 0.753) compared to existing risk scores.
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