Key result
An ACEF II score ≥1.461 predicted major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease after PCI with 79.4% sensitivity and 53.7% specificity (AUC 0.718).
Why the study?
To investigate the predictive value of the ACEF II score for MACCE in patients with coronary heart disease after PCI.
Does the ACEF II score predict the incidence of major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease after percutaneous coronary intervention?
Observational (n=445)
Does the ACEF II score predict the incidence of major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease after percutaneous coronary intervention?
Effect estimate: AUC 0.718
The ACEF II score is an effective tool for risk stratification and predicting long-term major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease undergoing PCI.
May support post-PCI risk stratification; leaves open prospective validation before clinical use.
Objective To investigate the predictive value of age, creatinine and ejection fraction (ACEF) II score for the incidence of major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Methods A total of 445 patients with CHD who underwent PCI were consecutively enrolled. The receiver operating characteristic (ROC) curve was used to analyse the power of the ACEF II score in predicting MACCE. Kaplan-Meier survival curves and log-rank tests were chosen for survival analysis of adverse prognosis between groups. Finally, multivariate Cox proportional risk regression analysis was used to investigate independent risk factors for MACCEs in patients with CHD after PCI. Results There was a significantly higher incidence of MACCEs in patients with high ACEF II scores. The area under the ROC curve of ACEF II score was 0.718, suggesting it had ideal predictive value for MACCE risks. The ACEF II score had a best cut-off value of 1.461 (sensitivity 79.4%, specificity 53.7%). Survival analysis indicated that patients in the high-score group had a significantly lower cumulative MACCE-free survival rate. Multivariate Cox regression analysis showed that ACEF II scores ≥1.461, Gensini scores ≥61.5, age, cardiac troponin I and previous PCI were independent risk factors of MACCE in patients with CHD after PCI, while the utilisation of statins was an independent protective factor. Conclusions The ACEF II score has an ideal capacity for risk stratification in patients with CHD undergoing PCI and offers good predictive value for MACCE in the long term.
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Wu et al. (2022) conducted an observational in Coronary heart disease after percutaneous coronary intervention (n=445). High ACEF II score (≥1.461) vs. Low ACEF II score (<1.461) was evaluated on Major adverse cardiovascular and cerebrovascular events (MACCEs) (AUC 0.718). An ACEF II score ≥1.461 predicted major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease after PCI with 79.4% sensitivity and 53.7% specificity (AUC 0.718).
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