Population
Single, human gingival fibroblasts grown on flexible bottom Petriperm dishes and loaded with fura-2/AM
Comparison
Mechanical stretching of flexible culture… vs 1% stretch of substrate area or unstretched state
Design
Preclinical
Follow-up
Up to 2,000 seconds
Authors
Loading...
Does not support clinical changes in periodontal care; leaves open the in vivo role of stretch-induced calcium oscillations in fibroblasts.
Mechanical stretching of human gingival fibroblasts induces intracellular calcium oscillations that are dependent on stretch-activated channels, L-type calcium channels, tyrosine kinases, G-proteins, and actin filaments.
Arora et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: