Key result
During spontaneous membrane potential oscillations in L-strain fibroblasts, cyclic membrane hyperpolarization coincides with a cyclic increase in intracellular free Ca2+ from 0.88 uM to 1.37 uM.
Population
L-strain fibroblasts
Design
Preclinical
Authors
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Highlights Ca2+-membrane coupling in fibroblasts; leaves open relevance to cardiac electrophysiology.
Absolute Event Rate: 1.37% vs 0.88%
Demonstrates that oscillatory hyperpolarization in fibroblasts is driven by cyclic increases in intracellular free Ca2+ activating K+ conductance.
Ueda et al. (1983) studied In vitro L-strain fibroblasts (n=4). Membrane potential oscillations vs. Depolarized state was evaluated on Intracellular free Ca2+ concentration. During spontaneous membrane potential oscillations in L-strain fibroblasts, cyclic membrane hyperpolarization coincides with a cyclic increase in intracellular free Ca2+ from 0.88 uM to 1.37 uM.
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