Key result
24-hour sodium deprivation increased plasma endothelin in salt-sensitive hypertensive patients (0.8+/-0.3 fmol/mL) compared to a decrease in salt-resistant patients (-0.4+/-0.3 fmol/mL) (P<0.04).
Why the study?
Does 24-hour sodium deprivation alter plasma endothelin levels in patients with salt-sensitive essential hypertension?
Population
47 patients with essential hypertension and 20 control subjects. A subset of 29 hypertensive patients…
Comparison
24-hour sodium deprivation vs Baseline state and normotensive control subjects
Design
Cohort
Follow-up
24 hours
Authors
Loading...
Suggests endothelin involvement in salt-sensitive hypertension during sodium restriction; leaves open clinical utility of endothelin blockade.
Observational (n=67)
Does 24-hour sodium deprivation alter plasma endothelin levels in patients with salt-sensitive essential hypertension?
Absolute Event Rate: 0.8% vs -0.4%
p-value: p=<0.04
Salt-depleted salt-sensitive hypertensive patients exhibit enhanced catecholamine-stimulated endothelin levels, suggesting they may respond better to endothelin receptor blockers.
Elijovich et al. (2001) conducted an observational in Essential hypertension (n=67). 24-hour sodium deprivation vs. Salt-resistant and indeterminate hypertensive patients was evaluated on Change in plasma endothelin in response to 24-hour sodium deprivation (p=<0.04). 24-hour sodium deprivation increased plasma endothelin in salt-sensitive hypertensive patients (0.8+/-0.3 fmol/mL) compared to a decrease in salt-resistant patients (-0.4+/-0.3 fmol/mL) (P<0.04).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: