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November 1, 1985The Journal of Infectious DiseasesOpen Access

Epstein-Barr Virus Infections and DNA Hybridization Studies in Posttransplantation Lymphoma and Lymphoproliferative Lesions: The Role of Primary Infection

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Authors

MHM. HoUniversity Health NetworkGMGeorge MillerYale UniversityRARobert W. AtchisonRutgers, The State University of New Jersey

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Implication

Randomized trial examines the link between Epstein-Barr virus infections and lymphoma in transplant patients, suggesting a significant risk factor for tumor development.

Key Points

  • This research investigates the relationship between Epstein-Barr virus infections and the development of lymphomas in transplant recipients.
  • Examined 14 patients with B cell lymphomas or lymphoproliferative lesions post-transplantation from 1981-1983.
  • Compared incidence of EBV infections in transplant patients with tumors and those without tumors.
  • Analyzed tumors for presence of EBV nuclear antigen and EBV genomes using DNA-DNA hybridization.
  • 30% of transplant patients without tumors had EBV infections, indicating higher frequency of active infection in those with tumors.
  • Primary infections were linked to a greater risk of developing tumors; five out of 13 tumors tested positive for EBV nuclear antigen.
  • Nine out of 11 tumors contained EBV genomes, established through DNA-DNA hybridization with specific probes.

Cite This Study

Ho et al. (1985) studied this question.

synapsesocial.com/papers/6a20da0bf76165bc1becb9dchttps://doi.org/10.1093/infdis/152.5.876
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Also Consider

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  1. 1Endogenous Reactivation of Epstein-Barr Virus Infections1977 · 91 citations
  2. 2Epstein-Barr Virus (EBV) Induced Polyclonal and Monoclonal B-Cell Lymphoproliferative Diseases Occurring after Renal Transplantation1983 · 423 citations
  3. 3Persisting Illness and Fatigue in Adults with Evidence of Epstein-Barr Virus Infection1985 · 550 citations