Why the study?
Do the immunosuppressants cyclosporin (CsA) and FK506 prevent the development of cardiac hypertrophy in animal models?
Do the immunosuppressants cyclosporin (CsA) and FK506 prevent the development of cardiac hypertrophy in animal models?
Calcineurin inhibition with cyclosporin or FK506 prevents cardiac hypertrophy in animal models of intrinsic cardiomyopathy and pressure overload.
Hypothesis-generating in animal models; leaves open whether calcineurin inhibition prevents human cardiac hypertrophy.
Mark A. Sussman et al . ([1][1]) report that the immunosuppressants cyclosporin (CsA) and FK506 prevent the development of hypertrophy in transgenic mouse models of intrinsic cardiomyopathy and, of more general import, in a rat model of extrinsic pressure-overload hypertrophy caused by banding of
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Müller et al. (1998) studied this question.
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