Why the study?
Does late echocardiographic monitoring detect asymptomatic cardiac dysfunction in patients who had normal cardiac monitoring during childhood anthracycline therapy?
Does late echocardiographic monitoring detect asymptomatic cardiac dysfunction in patients who had normal cardiac monitoring during childhood anthracycline therapy?
Late asymptomatic cardiac dysfunction and impaired myocardial growth can occur years after childhood anthracycline therapy despite normal echocardiograms during treatment, highlighting the need for long-term serial monitoring.
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Late monitoring may detect asymptomatic LV dysfunction in anthracycline survivors; leaves open whether serial echocardiography improves long-term outcomes.
Johnson et al. (1996) studied this question.
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