Why the study?
Does hydrochlorothiazide, hydralazine, or their combination alter intrarenal hemodynamics in spontaneously hypertensive and normotensive rats?
Population
Male spontaneously hypertensive and normotensive Wistar Kyoto rats (19 weeks old)
Comparison
Hydrochlorothiazide 80 mg/kg/d, hydralazine 5… vs Vehicle (control)
Design
Preclinical
Follow-up
3 weeks
Authors
Loading...
May promote glomerular ischemia in hypertensive models; hypothesis-generating for thiazide renal effects in humans.
Does hydrochlorothiazide, hydralazine, or their combination alter intrarenal hemodynamics in spontaneously hypertensive and normotensive rats?
Hydrochlorothiazide increases efferent glomerular resistance and induces glomerular ischemia in spontaneously hypertensive rats, potentially explaining the lack of improved renal target-organ damage in clinical trials.
Komatsu et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: