Why the study?
Does hydrochlorothiazide reverse or exacerbate nephrosclerosis and glomerular hypertension in L-NAME-treated spontaneously hypertensive rats?
Population
20-week-old male spontaneously hypertensive rats (SHR)
Comparison
Hydrochlorothiazide 80 mg/kg per day by gavage… vs L-NAME 50 mg/l alone for 3 weeks, and an…
Design
Preclinical
Follow-up
3 weeks
Authors
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HCTZ may worsen glomerular hypertension in this NO-blockade model; hypothesis-generating for thiazide effects on human nephrosclerosis.
Does hydrochlorothiazide reverse or exacerbate nephrosclerosis and glomerular hypertension in L-NAME-treated spontaneously hypertensive rats?
In a rat model of NO-blockade nephrosclerosis, hydrochlorothiazide exacerbated glomerular hypertension, proteinuria, and histopathological renal injury rather than reversing it.
Ono et al. (1996) studied this question.
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