Why the study?
Does prolonged nitric oxide synthase inhibition with L-NAME induce apoptosis and glomerular injury in spontaneously hypertensive rats?
Does prolonged nitric oxide synthase inhibition with L-NAME induce apoptosis and glomerular injury in spontaneously hypertensive rats?
Inhibition of nitric oxide synthesis in hypertensive rats activates angiotensin II, leading to glomerular cell apoptosis and severe nephrosclerosis.
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May elucidate NO-angiotensin pathways in hypertensive nephrosclerosis models; leaves open human translation and clinical relevance.
Ono et al. (2001) studied this question.
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