April 1, 2000Journal of the American Society of Nephrology

Locally Activated Renin-Angiotensin System Associated with TGF-β1 as a Major Factor for Renal Injury Induced by Chronic Inhibition of Nitric Oxide Synthase in Rats

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Population

Wistar rats

Comparison

N-nitro-L-arginine methyl ester given orally for… vs Control rats

Design

Preclinical

Follow-up

12 weeks

Authors

MKMinoru KashiwagiKonica Minolta (Japan)MSMichiya ShinozakiKawasaki Hospital HHHideki HirakataSaiseikai Fukuoka General Hospital

Discussion

Member takes

Implication

Does not support clinical use of RAS blockade for nitric oxide-related renal injury; hypothesis-generating for angiotensin-TGF-beta1 mechanisms in experimental models.

Structured PICO

Population

Wistar rats

Intervention

N(omega)-nitro-L-arginine methyl ester (L-NAME) given orally for 12 weeks, with or without an angiotensin-converting enzyme inhibitor, angiotensin II type 1 receptor antagonist, or hydralazine

Comparator

Control rats

Outcome

Renal injury (blood pressure, urinary protein excretion, glomerulosclerosis, interstitial fibrosis) and expression of TGF-beta1 and renin-angiotensin system componentssurrogate

Renal injury induced by chronic nitric oxide synthase inhibition in rats is primarily driven by local renin-angiotensin system activation and TGF-beta1 expression, which can be prevented by RAS blockade.

Cite This Study

Kashiwagi et al. (2000) studied this question.

synapsesocial.com/papers/6a7dbac0d0946debe915023f https://doi.org/10.1681/asn.v114616

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Implication

Does not support clinical use of RAS blockade for nitric oxide-related renal injury; hypothesis-generating for angiotensin-TGF-beta1 mechanisms in experimental models.

Locally Activated Renin-Angiotensin System Associated with TGF-β1 as a Major Factor for Renal Injury Induced by Chronic Inhibition of Nitric Oxide Synthase in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Locally Activated Renin-Angiotensin System Associated with TGF-β1 as a Major Factor for Renal Injury Induced by Chronic Inhibition of Nitric Oxide Synthase in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider