What question did this study set out to answer?

To analyze the relationship between plasma volume and interstitial fluid volume in men with essential hypertension compared to normal subjects.

September 1, 1969Circulation

Relation of Plasma to Interstitial Fluid Volume in Essential Hypertension

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Why the study?

Does the ratio of plasma volume to interstitial fluid volume differ between men with uncomplicated, untreated essential hypertension and normal subjects?

Population

Men with uncomplicated, untreated essential hypertension and normal subjects

Design

Cross-sectional

Authors

RTRobert C. TaraziGeneral / Preventive / Lipids HDHarriet P. DustanGeneral / Preventive / Lipids EFEdward D. FröhlichGeneral Cardiology

Discussion

Member takes

Implication

Should not alter hypertension management; hypothesis-generating for extracellular fluid regulation and requires prospective validation.

Key Points

To analyze the relationship between plasma volume and interstitial fluid volume in men with essential hypertension compared to normal subjects.
Measured extracellular water, plasma volume, and peripheral plasma renin activity in hypertensive and normal subjects.
Compared plasma to interstitial fluid volume ratios between groups.
Analyzed the correlation between plasma volume and renin activity.
Hypertensive patients had a significantly lower PV/IF ratio of 0.194 compared to 0.223 in normal subjects (P < 0.001).
Diminished plasma volume in hypertensive patients was 17.3 ml/cm of body height versus 18.7 ml/cm in normals (P < 0.05).
Three normal subjects with lower plasma volume maintained a normal PV/IF ratio of 0.224, indicating other factors at play.

Structured PICO

Does the ratio of plasma volume to interstitial fluid volume differ between men with uncomplicated, untreated essential hypertension and normal subjects?

Population

Men with uncomplicated, untreated essential hypertension and normal subjects

Comparator

Normal subjects

Outcome

Ratio of plasma volume to interstitial fluid volume (PV/IF)surrogate

Men with essential hypertension exhibit a significantly lower ratio of plasma volume to interstitial fluid volume, suggesting an abnormality in the regulation of extracellular water distribution.

Cite This Study

Tarazi et al. (1969) studied this question.

synapsesocial.com/papers/6a20f55b34bef10fdaeb2d67 https://doi.org/10.1161/01.cir.40.3.357

Topics

Hypertension management

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Relation of Plasma to Interstitial Fluid Volume in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Relation of Plasma to Interstitial Fluid Volume in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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