What question did this study set out to answer?

To examine differences in body fluid volumes, plasma renin activity, and hemodynamic relationships between patients with chronic renal insufficiency and essential hypertension.

January 12, 1981Acta Medica Scandinavica

Renin and Body Fluid Volumes in Chronic Renal Disease

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Why the study?

How do body fluid volumes and renin activity differ between patients with chronic renal insufficiency and essential hypertension under moderate salt restriction?

Population

85 patients, comprising 47 with hypertension and chronic renal insufficiency and 38 with essential…

Comparison

Moderate salt restriction vs Patients with essential hypertension compared to…

Design

Cross-sectional

Authors

PBPeter de BoerRadiotherapeutisch Instituut Friesland EME. J. Dorhout MeesRijksmuseum JRJan C. RoosAmsterdam UMC Location Vrije Universiteit Amsterdam

Discussion

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Implication

Suggests altered volume-renin dynamics in CRI; hypothesis-generating for management, pending prospective validation.

Key Points

To examine differences in body fluid volumes, plasma renin activity, and hemodynamic relationships between patients with chronic renal insufficiency and essential hypertension.
Evaluated 47 patients with hypertension and chronic renal insufficiency and 38 patients with essential hypertension maintained on moderate dietary salt restriction.
Measured plasma volume, blood volume, extracellular fluid volume, blood volume to interstitial fluid volume ratio, recumbent plasma renin activity, standing renin response, creatinine clearance, and mean arterial pressure.
Mean plasma volume, blood volume, and blood-to-interstitial volume ratio were significantly elevated in chronic renal insufficiency, whereas postural renin increase was markedly blunted (p<0.001) and weakly correlated with creatinine clearance (r=0.33).
Mean arterial pressure, resting plasma renin activity, and extracellular fluid volume did not differ significantly between groups; however, mean arterial pressure weakly correlated with extracellular fluid volume (r=0.34) and negatively with the blood-to-interstitial ratio (r=-0.31) in renal disease.

Structured PICO

How do body fluid volumes and renin activity differ between patients with chronic renal insufficiency and essential hypertension under moderate salt restriction?

Population

85 patients, comprising 47 with hypertension and chronic renal insufficiency (CRI) and 38 with essential hypertension (EH).

Intervention

Moderate salt restriction (observational assessment)

Comparator

Patients with essential hypertension (EH) compared to those with chronic renal insufficiency (CRI)

Outcome

Plasma volume (PV), blood volume (BV), extracellular fluid volume (ECFV), ratio of blood volume to interstitial fluid volume (BV/IV), recumbent plasma renin activity (PRA), increase in PRA upon standing (ΔPRAst), creatinine clearance (Ccr), and mean arterial pressure (MAP)surrogate

Patients with chronic renal insufficiency exhibit decreased tissue compliance leading to relative blood volume elevation and a blunted renin response to standing compared to those with essential hypertension.

Cite This Study

Boer et al. (1981) studied this question.

synapsesocial.com/papers/6a8d1de20b453ccb7788db9f https://doi.org/10.1111/j.0954-6820.1981.tb09802.x

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Renin and Body Fluid Volumes in Chronic Renal Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Renin and Body Fluid Volumes in Chronic Renal Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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