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January 25, 2018Journal of Clinical HypertensionOpen Access

Renal denervation improves 24‐hour central and peripheral blood pressures, arterial stiffness, and peripheral resistance

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Why the study?

Does renal denervation improve ambulatory blood pressure, arterial stiffness, and peripheral resistance in patients with treatment resistant hypertension?

Population

94 patients with treatment resistant hypertension (TRH)

Design

Cohort

Follow-up

12 months

Key result

Renal denervation significantly reduced brachial and central ambulatory blood pressure (P<.001) and improved arterial stiffness and total vascular resistance at up to 12 months.

Authors

COChristian OttKFKlaas FranzenTGTobias Graf

Discussion

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Overview

Supports renal denervation evaluation in resistant hypertension; leaves open randomized confirmation of ambulatory BP and vascular benefits.

Study Design

Type

Cohort (n=94)

Structured PICO

Does renal denervation improve ambulatory blood pressure, arterial stiffness, and peripheral resistance in patients with treatment resistant hypertension?

P
Population
94 patients with treatment resistant hypertension who underwent renal denervation, followed for up to 12 months.
E
Exposure
Renal denervation (RDN)
O
Outcome
Ambulatory blood pressure (brachial and central), hemodynamics, and arterial stiffness measured at 3, 6, and 12 monthssurrogate

Main Result

p-value: p=<.001

Renal denervation significantly reduces brachial and central ambulatory blood pressure, arterial stiffness, and total vascular resistance up to 12 months in patients with treatment-resistant hypertension.

Cite This Study

Ott et al. (2018) conducted a cohort in Treatment resistant hypertension (TRH) (n=94). Renal denervation (RDN) was evaluated on Brachial and central ambulatory blood pressure (p=<.001). Renal denervation significantly reduced brachial and central ambulatory blood pressure (P<.001) and improved arterial stiffness and total vascular resistance at up to 12 months.

synapsesocial.com/papers/6a20f6fa920f77b2c049eee1https://doi.org/10.1111/jch.13193
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