Why the study?
Does renal denervation reduce 24-hour ambulatory blood pressure in patients with resistant hypertension?
Does renal denervation reduce 24-hour ambulatory blood pressure in patients with resistant hypertension?
Renal denervation significantly reduces 24-hour ambulatory blood pressure as early as 1 month in approximately half of patients with resistant hypertension.
Answers are grounded in this paper and cite their sources.
May indicate early office SBP response to renal denervation; leaves open ambulatory BP effects and requires randomized confirmation before practice change.
Although guidelines recommend ambulatory blood pressure (BP) monitoring (ABPM), few data are available regarding the effects of renal denervation (RDN) on 24-hour ABPM values. A total of 44 patients with mean systolic BP ≥135 mm Hg on ABPM despite adequate therapy were included. Basal systolic BP (SBP) and diastolic BP (DBP) were 154±11 mm Hg and 86±12 mm Hg, respectively. At 1 month, SBP and DBP were reduced to 146±18 mm Hg (P=.01) and 82±14 mm Hg and showed no further decrease up to 6 months. Only 55% of the patients responded to RDN (≥-5 mm Hg SBP), with a mean responder rate drop of 21/11 mm Hg. Neither the number of ablation points nor the amount of impedance drop was predictive of response. Only approximately half of patients with resistant hypertension responded to RDN. However, in these responders, a remarkable reduction of 24-hour BP occurred as early as 1 month after RDN.
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Schwerg et al. (2014) studied this question.
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