Key result
Catheter-based renal denervation significantly reduced clinic systolic blood pressure by 15.1 mm Hg (95% CI, -23.4 to -6.8; P=.001) at 6 months in patients with uncontrolled hypertension.
Why the study?
Does catheter-based renal denervation reduce blood pressure in patients with uncontrolled hypertension and confirmed medication adherence?
Observational (n=34)
Yes
Does catheter-based renal denervation reduce blood pressure in patients with uncontrolled hypertension and confirmed medication adherence?
Mean Difference: -15.1 (95% CI -23.4–-6.8)
p-value: p=.001
In routine clinical care, catheter-based renal denervation significantly reduced clinic blood pressure at 6 months in patients with confirmed adherent, uncontrolled hypertension, though ambulatory blood pressure reductions were not statistically significant.
Renal denervation may lower BP in adherent resistant hypertension; leaves open efficacy pending randomized confirmation.
Renal denervation (RDN) has emerged as a potential device-based treatment for resistant hypertension. The authors present their experience of the use of catheter-based RDN as part of routine clinical care in two specialist hypertension clinics. Thirty-four patients with uncontrolled hypertension underwent RDN. All patients had ambulatory blood pressure (BP) monitoring and directly observed medication administration prior to the procedure to exclude white-coat hypertension and nonadherence, respectively. Overall, there was a significant change in clinic systolic BP of -15.1 mm Hg (95% confidence interval, -23.4 to -6.8; P=.001) and clinic diastolic BP of -6.2 mm Hg (95% confidence interval, -11.5 to -0.9; P=.02) 6 months postprocedure, and a nonsignificant change in daytime ambulatory BP of -5.4/-2.9 mm Hg. Eighteen patients (51.4%) showed a significant reduction in their clinic systolic BP (≥10 mm Hg) and 16 (47%) had a significant reduction in their daytime ambulatory systolic BP (≥5 mm Hg) at 6 months.
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Hameed et al. (2015) conducted an observational in Uncontrolled hypertension (n=34). Catheter-based renal denervation was evaluated on Change in clinic systolic blood pressure at 6 months (MD -15.1 mm Hg, 95% CI -23.4 to -6.8, p=.001). Catheter-based renal denervation significantly reduced clinic systolic blood pressure by 15.1 mm Hg (95% CI, -23.4 to -6.8; P=.001) at 6 months in patients with uncontrolled hypertension.
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