Key result
A coupled biventricular finite element and circulatory system model demonstrated significantly increased myofibre stress and decreased pump function in a canine heart with dilated cardiomyopathy.
A novel weakly coupled computational model of the heart and circulatory system accurately simulates hemodynamics and biomechanics in heart failure with reduced computational time.
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Highlights computational modeling of DCM biomechanics; leaves open human translation and validation.
Wenk et al. (2012) studied Heart failure and dilated cardiomyopathy. Coupled biventricular finite element and lumped-parameter circulatory system model vs. Healthy canine heart model was evaluated on Cardiac function and myofibre stress. A coupled biventricular finite element and circulatory system model demonstrated significantly increased myofibre stress and decreased pump function in a canine heart with dilated cardiomyopathy.
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