July 1, 1997Clinical Science

Inhibition of Neutral Endopeptidase, the Degradative Enzyme for Natriuretic Peptides, in rat Kidney after Oral SCH 42495

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Why the study?

Does oral SCH 42495 inhibit renal neutral endopeptidase in adult normotensive Sprague-Dawley rats?

Population

Adult normotensive Sprague-Dawley rats and in vitro rat renal NEP

Comparison

Oral SCH 42495 in vivo; SCH 42354 in vitro vs Enalaprilat (in vitro); control (in vivo)

Design

Preclinical

Follow-up

up to 48 h

Authors

LBLouise M. BurrellHeart Failure & Transplant NFNicole K. FarinaThe University of Melbourne JRJohn RisvanisThe University of Melbourne

Discussion

Member takes

Implication

Supports oral NEP inhibitor development in rats; leaves open human translation and clinical testing.

Structured PICO

Does oral SCH 42495 inhibit renal neutral endopeptidase in adult normotensive Sprague-Dawley rats?

Population

Adult normotensive Sprague-Dawley rats and in vitro rat renal NEP

Intervention

Oral SCH 42495 (3-300 mg/kg) in vivo; SCH 42354 in vitro

Comparator

Enalaprilat (in vitro); control (in vivo)

Outcome

Inhibition of renal neutral endopeptidase (NEP)surrogate

Short-term administration of the NEP inhibitor SCH 42495 significantly inhibits renal NEP without affecting the circulating or tissue renin-angiotensin system in rats.

Cite This Study

Burrell et al. (1997) studied this question.

synapsesocial.com/papers/6a2115ac23521dddf4c3bf02 https://doi.org/10.1042/cs0930043

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Inhibition of Neutral Endopeptidase, the Degradative Enzyme for Natriuretic Peptides, in rat Kidney after Oral SCH 42495

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of Neutral Endopeptidase, the Degradative Enzyme for Natriuretic Peptides, in rat Kidney after Oral SCH 42495

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider