Why the study?
Does SCH 34826 increase urinary sodium excretion in healthy volunteers?
Population
8 healthy, normotensive volunteers who had maintained a high sodium intake for 5 days
Comparison
SCH 34826 at doses of 400, 800, and 1600 mg vs Placebo
Design
Other, single-blind
Follow-up
5 hours
Authors
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Natriuresis in healthy volunteers warrants patient trials; leaves open efficacy in HF or hypertension.
Does SCH 34826 increase urinary sodium excretion in healthy volunteers?
SCH 34826, an oral neutral metalloendopeptidase inhibitor, significantly increases urinary sodium and phosphate excretion in healthy volunteers without altering blood pressure or heart rate.
Burnier et al. (1991) studied this question.
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