Why the study?
Are alterations in adrenergic receptor densities associated with myocardial hibernation and contractile reserve in patients with ischemic ventricular dysfunction?
Are alterations in adrenergic receptor densities associated with myocardial hibernation and contractile reserve in patients with ischemic ventricular dysfunction?
Graded and reciprocal changes in α- and β-adrenergic receptor densities occur in viable, hibernating myocardium, potentially explaining depressed resting function and preserved contractile reserve.
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Receptor shifts may underlie hibernation and reserve loss; hypothesis-generating for targeted modulation in ischemic dysfunction.
Shan et al. (2000) studied this question.
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