Key result
Chronic heart failure was associated with significantly higher mean plasma levels of thioredoxin compared to healthy subjects (32 vs 12 ng/ml, P<0.0001).
Why the study?
Are circulating levels of thioredoxin and other stress markers elevated in patients with chronic heart failure compared to healthy controls?
Population
n=56 total; n=27 patients with chronic heart failure of NYHA class II and III, and n=29 healthy retired…
Design
Case-control
Authors
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Elevated thioredoxin may mark stress in chronic heart failure; hypothesis-generating and should not yet change practice.
Case-Control (n=56)
Are circulating levels of thioredoxin and other stress markers elevated in patients with chronic heart failure compared to healthy controls?
Absolute Event Rate: 32% vs 12%
p-value: p=<0.0001
Thioredoxin is significantly elevated in chronic heart failure patients compared to controls, correlating with disease severity and other stress markers, suggesting its role as an adaptive stress response.
Jekell et al. (2004) conducted a case-control in Chronic heart failure (n=56). Chronic heart failure vs. Healthy subjects was evaluated on Plasma levels of thioredoxin (Trx) (p=<0.0001). Chronic heart failure was associated with significantly higher mean plasma levels of thioredoxin compared to healthy subjects (32 vs 12 ng/ml, P<0.0001).