Key result
Coronary artery disease (HR 2.94; 95% CI 1.36-6.33) and diabetes mellitus (HR 2.00; 95% CI 1.68-2.38) were the strongest independent clinical risk factors for incident heart failure.
Why the study?
Are specific clinical factors associated with an increased risk of incident heart failure in unselected community populations?
Meta-Analysis (n=456,850)
Are specific clinical factors associated with an increased risk of incident heart failure in unselected community populations?
Hazard Ratio: 2.94 (95% CI 1.36–6.33)
Seven common clinical variables, notably coronary artery disease, diabetes, and age, strongly predict incident heart failure and can guide screening strategies.
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CAD and diabetes predict incident HF in community cohorts; extends meta-analytic evidence but prospective validation needed before guiding screening.
Yang et al. (2015) conducted a meta-analysis in incident heart failure (n=456,850). Clinical risk factors (e.g., coronary artery disease, diabetes) was evaluated on incident HF (HR 2.94, 95% CI 1.36 to 6.33). Coronary artery disease (HR 2.94; 95% CI 1.36-6.33) and diabetes mellitus (HR 2.00; 95% CI 1.68-2.38) were the strongest independent clinical risk factors for incident heart failure.
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