Key result
Angiotensin II and phenylephrine independently downregulate Kv4.3 gene expression in neonatal rat cardiac myocytes through different mechanisms (mRNA destabilization vs transcriptional inhibition).
Angiotensin II and phenylephrine independently downregulate Kv4.3 potassium channel expression in cardiac myocytes via distinct post-transcriptional and transcriptional mechanisms, respectively.
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Caution against extrapolating neonatal rat data to patients; leaves open distinct Kv4.3 regulatory pathways in human cardiac remodeling.
Zhang et al. (2001) studied Cardiac myocyte hypertrophy. Angiotensin II and phenylephrine was evaluated on Kv4.3 mRNA and protein expression. Angiotensin II and phenylephrine independently downregulate Kv4.3 gene expression in neonatal rat cardiac myocytes through different mechanisms (mRNA destabilization vs transcriptional inhibition).
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