Key result
Specific ablation of IL-17A signaling to Sca-1+ cardiac fibroblasts protected mice from post-infarct heart failure and death, identifying this subset as a key driver of cardiac inflammation.
Why the study?
Does specific ablation of IL-17A signaling to Sca-1+ cardiac fibroblasts prevent post-infarct heart failure and death in mouse models?
Population
Experimental autoimmune myocarditis and myocardial infarction mouse models, and cardiac biopsy samples from…
Design
Preclinical
Authors
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Does not support clinical translation yet; hypothesis-generating for IL-17A targeting in post-MI remodeling.
Does specific ablation of IL-17A signaling to Sca-1+ cardiac fibroblasts prevent post-infarct heart failure and death in mouse models?
Identification of a pathological GM-CSF-producing Sca-1+ cardiac fibroblast subset that drives heart failure development provides a novel mechanistic insight and potential therapeutic target.
Chen et al. (2018) studied Heart failure. Specific ablation of IL-17A signaling to Sca-1+ periostin+ cardiac fibroblasts was evaluated on Post-infarct heart failure and death. Specific ablation of IL-17A signaling to Sca-1+ cardiac fibroblasts protected mice from post-infarct heart failure and death, identifying this subset as a key driver of cardiac inflammation.
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