Key result
Substituting commonly used antihypertensive drugs with vasodilators such as alpha-blockers, ACE inhibitors, and calcium blockers may provide maximal efficacy and long-term safety.
Why the study?
Does substituting older antihypertensives with vasodilators improve protection against cardiovascular disease and quality of life in asymptomatic patients with mild hypertension?
Population
Asymptomatic patients with relatively mild hypertension
Comparison
Non-drug therapies and vasodilators vs Commonly used drugs
Design
Review
Authors
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Should not yet change practice in mild hypertension; leaves open whether vasodilators improve cardiovascular protection or quality of life.
Does substituting older antihypertensives with vasodilators improve protection against cardiovascular disease and quality of life in asymptomatic patients with mild hypertension?
This review suggests that newer vasodilating antihypertensives may offer better protection and quality of life than older agents for the management of mild hypertension.
Norman M. Kaplan (1988) conducted a review in Hypertension. Vasodilators (alpha-blockers, ACE inhibitors, calcium blockers) vs. Diuretics, central agonists, and beta-blockers was evaluated. Substituting commonly used antihypertensive drugs with vasodilators such as alpha-blockers, ACE inhibitors, and calcium blockers may provide maximal efficacy and long-term safety.