Why the study?
Little is known about the prognosis and long-term effects of EV and HPeV meningitis in children, and reasons for differences in clinical presentation remain unclear.
This review highlights the mechanisms of EV and HPeV meningitis in children, emphasizing the need for more research on long-term neurological outcomes.
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Hypothesis-generating for EV/HPeV mechanisms in pediatric meningitis; leaves long-term neurological outcomes open for prospective study.
Enterovirus (EV) and Parechovirus (HPeV) are a frequent cause of infection in children. This review gives an overview of possible causes for differences in clinical presentation. EV and HPeV can cause a meningitis with or without pleocytosis. Different possible mechanisms for meningitis without pleocytosis are given. Little is known about the prognosis and long-term effects of EV and HPeV meningitis in children. Only some studies with a small number of children with EV or HPeV meningitis are reported. The different possible mechanisms involved in the neurological outcome after EV or HPeV meningitis will be discussed.
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Stephanie C. de CROM (2019) studied this question.
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