Key result
Short-term aldosterone infusions decreased glomerular ANG II receptor density by 33% and 45% at two infusion rates, an effect that was abolished by spironolactone.
Why the study?
Does short-term administration of corticosteroids (aldosterone or dexamethasone) reduce glomerular ANG II receptor density in vivo?
Does short-term administration of corticosteroids (aldosterone or dexamethasone) reduce glomerular ANG II receptor density in vivo?
Corticosteroids (both mineralocorticoids and glucocorticoids) downregulate glomerular ANG II receptors, which may diminish ANG II's influence on glomerular hemodynamics in steroid-induced hypertension.
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May modulate glomerular hemodynamics in steroid hypertension; hypothesis-generating for mineralocorticoid effects on ANG II receptors.
J G Douglas (1987) studied this question. Aldosterone and dexamethasone was evaluated on Glomerular ANG II receptor density. Short-term aldosterone infusions decreased glomerular ANG II receptor density by 33% and 45% at two infusion rates, an effect that was abolished by spironolactone.
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