Key result
Acute elevation of plasma free fatty acids via Intralipid/heparin infusion blocks insulin-mediated glucose uptake and capillary recruitment in anesthetized rats.
Why the study?
Does lipid infusion impair insulin-mediated capillary recruitment and muscle glucose uptake in anesthetized rats?
Does lipid infusion impair insulin-mediated capillary recruitment and muscle glucose uptake in anesthetized rats?
Acute elevation of plasma free fatty acids blocks insulin-mediated glucose uptake and capillary recruitment in an animal model.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for lipid effects on microvascular insulin action; leaves open human relevance and requires prospective validation.
Clerk et al. (2002) studied Insulin resistance. Intralipid/heparin infusion vs. Saline infusion was evaluated on Insulin-mediated glucose uptake and capillary recruitment. Acute elevation of plasma free fatty acids via Intralipid/heparin infusion blocks insulin-mediated glucose uptake and capillary recruitment in anesthetized rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: