Key result
Myocardial extracellular volume fraction (ECV) quantified using a novel ECG-less, free-breathing CMR Multitasking technique was significantly higher in the HFpEF rat group compared to controls (22.4% vs. 18.0%, P = 0.0010).
Why the study?
Acquiring high-quality myocardial T1 and ECV maps in small animals is technically challenging due to high heart rates and high respiration rates.
Can motion-resolved CMR Multitasking quantify myocardial extracellular volume fraction without ECG triggering or respiratory gating in a rat HFpEF model?
Population
9 high-salt fed rats with HFpEF and 9 control rats
Comparison
High-salt fed HFpEF rats vs control rats imaged with ECV Multitasking
Design
Preclinical feasibility study
Authors
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May enable preclinical HFpEF fibrosis studies; leaves open human validation of ECG-less ECV Multitasking.
Can motion-resolved CMR Multitasking quantify myocardial extracellular volume fraction without ECG triggering or respiratory gating in a rat HFpEF model?
Absolute Event Rate: 22.4% vs 18%
p-value: p=0.0010
Motion-resolved ECV Multitasking CMR can quantify ECV in rat myocardium at high heart rates without ECG triggering or respiratory gating, successfully detecting elevated ECV in a HFpEF model that correlates with histological fibrosis.
Han et al. (2021) studied Heart failure with preserved ejection fraction (HFpEF) (n=18). High-salt diet induced HFpEF vs. Normal-salt diet (Control) was evaluated on Myocardial extracellular volume fraction (ECV) (p=0.0010). Myocardial extracellular volume fraction (ECV) quantified using a novel ECG-less, free-breathing CMR Multitasking technique was significantly higher in the HFpEF rat group compared to controls (22.4% vs. 18.0%, P = 0.0010).
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