August 1, 1990Journal of Bone and Joint Surgery

Pharmacological regulation of the circulation of bone.

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Population

Skeletally mature mongrel dogs (in vivo model with cannulated nutrient artery of the tibia)

Design

Preclinical, randomized sequence for each experiment

Authors

MBMark R. BrinkerTexas Medical Center HLHoward LipptonTulane University SCS. D. CookLittoral Research Group (United States)

Discussion

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Implication

Suggests asymmetric vasoreactivity in canine bone; leaves open translation to human orthopedic vascular conditions.

Structured PICO

Population

Skeletally mature mongrel dogs (in vivo model with cannulated nutrient artery of the tibia)

Intervention

Intra-arterial injection of vasoactive substances (nitroglycerin, acetylcholine, isoproterenol, methoxamine, U46619, dibutyryl cyclic AMP, 8-bromo-cyclic GMP, endothelin-1) and antagonists (atropine, ICI 118551, ONO 3708, prazosin)

Outcome

Changes in bone-perfusion pressure under conditions of constant blood flowsurrogate

The vascular bed of bone in dogs exhibits potent responses to vasoconstrictor mechanisms but weak responses to vasodilators.

Cite This Study

Brinker et al. (1990) studied this question.

synapsesocial.com/papers/6a219fe2153b2036cbf1e809 https://doi.org/10.2106/00004623-199072070-00002

View Full Paper

Ask AI

Bookmark

Pharmacological regulation of the circulation of bone.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacological regulation of the circulation of bone.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider