Key result
Low frequency stimulation of the lumbar sympathetic chain in dogs increased perfusion pressure, an effect reduced or abolished by alpha-adrenoceptor blocking agents but not beta-blockers.
Population
Anaesthetized dogs
Comparison
Low frequency stimulation of the lumbar… vs Baseline/unstimulated state
Design
Preclinical
Authors
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Alpha-adrenergic blockade may blunt sympathetic effects on bone perfusion; leaves open translation to human vascular regulation.
Lumbar sympathetic stimulation increases bone vascular perfusion pressure primarily via alpha-adrenergic receptors.
MARIE‐ANTOINETTE TRAN (1980) studied this question. Low frequency stimulation of the lumbar sympathetic chain was evaluated on Perfusion pressure in the artery, intramedullary pressure of the bone, and pressure in the nutrient vein. Low frequency stimulation of the lumbar sympathetic chain in dogs increased perfusion pressure, an effect reduced or abolished by alpha-adrenoceptor blocking agents but not beta-blockers.
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