Key result
Periarterial electrical stimulation and norepinephrine caused phentolamine-sensitive increases in perfusion pressure, while acetylcholine caused atropine-sensitive decreases in constrictions.
The isolated perfused dog tibia serves as a satisfactory experimental model to investigate the direct effects of sympathetic nerve stimulation and vasoactive amines on bone blood vessels.
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Validates isolated perfused dog tibia model for bone vascular studies; leaves open translation to human bone perfusion.
Driessens et al. (1979) studied Vascular reactivity of bone tissue. Nerve stimulation, norepinephrine, and acetylcholine was evaluated on Perfusion pressure (vascular reactivity). Periarterial electrical stimulation and norepinephrine caused phentolamine-sensitive increases in perfusion pressure, while acetylcholine caused atropine-sensitive decreases in constrictions.
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