Key result
Among CRT-D recipients, patients ≥80 years old had higher mortality (HR 1.39; 95% CI 1.12-1.72; P=0.003) but a lower rate of appropriate shocks compared to patients <80 years old.
Why the study?
Does age ≥80 years compared to <80 years affect mortality and the rate of appropriate shocks in heart failure patients receiving a CRT-D?
Population
1,316 consecutive patients with New York Heart Association II-IV heart failure, left ventricular ejection…
Comparison
Cardiac resynchronization therapy-defibrillator… vs Cardiac resynchronization therapy-defibrillator…
Design
Cohort
Follow-up
52 ± 36 months
Authors
Loading...
Supports age-stratified CRT-P vs CRT-D trials in HF; leaves open optimal device selection for octogenarians.
Cohort (n=1,316)
Does age ≥80 years compared to <80 years affect mortality and the rate of appropriate shocks in heart failure patients receiving a CRT-D?
Hazard Ratio: 1.39 (95% CI 1.12–1.72)
Absolute Event Rate: 48% vs 45%
p-value: p=0.003
In CRT-D recipients, patients ≥80 years old have higher mortality but significantly fewer appropriate shocks compared to younger patients, suggesting CRT-pacemakers (CRT-P) may be a more appropriate consideration for this elderly population.
Adelstein et al. (2015) conducted a cohort in Heart failure (n=1,316). Age ≥80 years vs. Age <80 years was evaluated on Mortality (HR 1.39, 95% CI 1.12-1.72, p=0.003). Among CRT-D recipients, patients ≥80 years old had higher mortality (HR 1.39; 95% CI 1.12-1.72; P=0.003) but a lower rate of appropriate shocks compared to patients <80 years old.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: