Key result
Intrapericardial injection of heat-killed staphylococci and adjuvant in sheep produced a reproducible model of pericarditis evolving through inflammatory, mesothelial injury, and fibrotic phases.
Authors
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Facilitates preclinical pericarditis research; leaves open translation to human disease and therapies.
Leak et al. (1987) studied Acute pericarditis. Surgical injection of heat-killed staphylococci and Freund's adjuvant was evaluated on Evolution of pericardial inflammation. Intrapericardial injection of heat-killed staphylococci and adjuvant in sheep produced a reproducible model of pericarditis evolving through inflammatory, mesothelial injury, and fibrotic phases.
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