Key result
Metoprolol administration significantly prolonged the absolute refractory periods of both the slow (398 vs 337 ms, P<0.01) and fast (517 vs 430 ms, P<0.01) pathways in patients with permanent AF.
Why the study?
Does metoprolol administration prolong the functional refractory period of the AV node in patients with permanent atrial fibrillation as assessed by non-invasive ECG?
Does metoprolol administration prolong the functional refractory period of the AV node in patients with permanent atrial fibrillation as assessed by non-invasive ECG?
p-value: p=<0.01
Non-invasive ECG evaluation confirms that metoprolol prolongs the functional refractory period of the AV node in patients with permanent atrial fibrillation.
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Supports metoprolol prolonging AV nodal refractoriness via non-invasive ECG in permanent AF; hypothesis-generating and requires randomized confirmation.
Corino et al. (2014) studied permanent atrial fibrillation (n=60). Metoprolol vs. Baseline was evaluated on absolute refractory periods of the slow and fast pathways (aRPs and aRPf) (p=<0.01). Metoprolol administration significantly prolonged the absolute refractory periods of both the slow (398 vs 337 ms, P<0.01) and fast (517 vs 430 ms, P<0.01) pathways in patients with permanent AF.
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