Why the study?
Do bisoprolol and metoprolol differ in their effects on atrial and AV nodal refractoriness and atrial fibrillatory rate during atrial fibrillation in pigs?
Population
12 open-chest pigs with induced atrial fibrillation
Comparison
Bisoprolol 0.1 mg/kg or metoprolol 0.3 mg/kg vs Baseline measurements before drug administration…
Design
Preclinical
Authors
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These porcine findings indicate limited beta-blocker impact on fibrillatory intervals under low sympathetic tone; leaves open translation to human AF.
Do bisoprolol and metoprolol differ in their effects on atrial and AV nodal refractoriness and atrial fibrillatory rate during atrial fibrillation in pigs?
In a pig model of atrial fibrillation with low sympathetic tone, beta-blockers exert insignificant effects on atrial fibrillatory rate, and the mild class I effect of metoprolol does not play a role.
Berg et al. (1997) studied this question.
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