Why the study?
Do metoprolol and amiodarone alter atrial and ventricular activity during atrial fibrillation in post-surgical patients?
Do metoprolol and amiodarone alter atrial and ventricular activity during atrial fibrillation in post-surgical patients?
Antiarrhythmic drugs like metoprolol and amiodarone reduce ventricular rate during atrial fibrillation primarily by altering AV nodal properties rather than atrial rhythm, a mechanism that can be accurately simulated using mathematical modeling.
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May support AV nodal selectivity of metoprolol/amiodarone for ventricular rate control in post-op AF; leaves open prospective validation.
Mangin et al. (2005) studied this question.
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