Key result
Exercise training augmented contractile responses in porcine collateral-dependent coronary arteries via enhanced calcium sensitization mediated by Rho-kinase and CaMKII.
Why the study?
Does exercise training enhance contractile responses and calcium sensitization in collateral-dependent coronary arteries in a porcine model of chronic occlusion?
Does exercise training enhance contractile responses and calcium sensitization in collateral-dependent coronary arteries in a porcine model of chronic occlusion?
Exercise training enhances contractile responses in collateral-dependent coronary arteries via calcium sensitization, potentially increasing resting arterial tone and coronary flow reserve.
Should not change exercise guidance in CAD; leaves open exercise effects on collateral vasoreactivity in humans.
Small coronary arteries distal to chronic occlusion displayed enhanced contractile responses, which were further augmented after exercise training and attributable to enhanced calcium sensitization without alterations in calcium channel current. The calcium sensitization mediators Rho-kinase and CaMKII significantly contributed to enhanced contraction in collateral-dependent arteries of exercise-trained, but not sedentary, pigs. Exercise-enhanced contractile responses may increase resting arterial tone, creating an enhanced coronary flow reserve that is accessible during periods of increased metabolic demand.
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Heaps et al. (2020) studied Chronic coronary occlusion. Exercise training vs. Sedentary was evaluated on Contractile responses and calcium sensitization in collateral-dependent arteries. Exercise training augmented contractile responses in porcine collateral-dependent coronary arteries via enhanced calcium sensitization mediated by Rho-kinase and CaMKII.
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