Key result
Heterotrimeric G protein alterations play a central role in transducing signals from membrane receptors, contributing to the pathogenesis of cardiac hypertrophy, heart failure, and arrhythmia.
Design
Review
Authors
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No immediate change to clinical management of HF or arrhythmia; leaves open G protein-targeted therapies for prospective validation.
This review summarizes the role of heterotrimeric G proteins as a switchboard between extracellular signals and intracellular effectors in the pathogenesis of cardiac hypertrophy, heart failure, and arrhythmia.
Zolk et al. (2000) conducted a review in Heart disease (cardiac hypertrophy, heart failure, arrhythmia). Heterotrimeric G proteins was evaluated. Heterotrimeric G protein alterations play a central role in transducing signals from membrane receptors, contributing to the pathogenesis of cardiac hypertrophy, heart failure, and arrhythmia.
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