Key result
In patients with stable heart failure, low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid were significantly associated with disease severity and total mortality.
Why the study?
Are altered plasma fatty acid levels associated with disease severity and mortality in patients with stable heart failure?
Observational (n=227)
Are altered plasma fatty acid levels associated with disease severity and mortality in patients with stable heart failure?
In patients with stable heart failure, specific alterations in plasma fatty acid composition, notably low eicosatetraenoic acid and high vaccenic acid, are associated with increased disease severity and total mortality.
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May inform risk stratification in stable HF; leaves open causality and need for interventional trials.
Øie et al. (2011) conducted an observational in Chronic heart failure (n=227). Fatty acid composition (low eicosatetraenoic acid and high vaccenic acid) vs. Healthy control subjects / normal fatty acid levels was evaluated on Disease severity and total mortality. In patients with stable heart failure, low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid were significantly associated with disease severity and total mortality.
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