Key result
Afferent renal nerve activity excitation during renal ischemia was more than 10-fold greater in spontaneously hypertensive rats compared to normotensive rats.
The study demonstrates that spontaneously hypertensive rats have a significantly exaggerated afferent renal nerve response to renal ischemia compared to normotensive rats.
May heighten ischemic vulnerability in hypertension; leaves open human translation for renal neuromodulation.
R2 chemoreceptors are excited by backflow of urine or isotonic KCl into the renal pelvis, they do not respond to backflow of isotonic saline at the same intrapelvic pressure but are excited during periods of renal ischemia. R1 chemoreceptors are excited during complete renal ischemia but otherwise exhibit no activity. The responses of multiunit afferent renal nerve activity (ARNA) to these stimuli in Sprague Dawley rats follow the same patterns exhibited by R2 chemoreceptors, and the data do not support the presence of mechanoreceptive nerves which are excited by increases in intrapelvic pressure in these animals. The responses of multiunit ARNA in SHR and WKY rats were not different from Sprague Dawley rats. In contrast, while the response of WKY rats during renal ischemia was not different from Sprague Dawley rats the excitation of SHR during ischemia was more than 10 fold greater than that of the normotensive animals.
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Nicholas Moss (1987) studied this question. Renal ischemia and intrapelvic stimuli vs. Normotensive rats (WKY and Sprague Dawley) was evaluated on Afferent renal nerve activity (ARNA) response. Afferent renal nerve activity excitation during renal ischemia was more than 10-fold greater in spontaneously hypertensive rats compared to normotensive rats.
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