Key result
An oscillatory shear index-based computational model demonstrated progressive stenosis with significant increases in high OSI regions in 6 of 11 patient-derived carotid arteries.
Why the study?
This study aimed to describe and demonstrate the applicability of a novel in silico method for modeling progressive carotid artery stenosis using the oscillatory shear index as the basis of stenosis.
This novel in silico method provides a framework for computational hemodynamic investigations on progressive atherosclerosis in the carotid artery.
Answers are grounded in this paper and cite their sources.
OSI modeling may advance carotid atherosclerosis research; leaves open clinical translation pending in vivo validation.
Background and aims : This study describes and demonstrates the applicability of a novel in silico method for modeling progressive carotid artery stenosis using the oscillatory shear index (OSI) as the basis of stenosis. Methods : Three-dimensional reconstructions of 11 carotid arteries were generated using patient-derived magnetic resonance angiography and duplex ultrasound data. Computational fluid dynamic simulations were sequentially generated following computational stenosis assessment, and corresponding changes in OSI were observed and used as measure of morphological stabilization. Results : 6 carotid models showed progressive stenosis with statistically significant increases in regions of high OSI (OSI >.2, P < .05) with eventual carotid occlusion in 1 of the cases. Three models remained free or nearly free of increased OSI, whereas 1 model showed an overall decrease in high OSI regions (P < .05) and another trended in that direction but did not achieve statistical significance ( P = .145). Conclusions : To our knowledge, this is the first computational model describing progressive stenosis in any peripheral artery including the carotid. Taken together, this study provides a novel framework for computational hemodynamic investigations on progressive atherosclerosis in the carotid artery.
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Peter Patalano (2022) studied Carotid artery stenosis (n=11). Oscillatory shear index (OSI)-based computational modeling was evaluated on Progressive stenosis and changes in OSI (p=<.05). An oscillatory shear index-based computational model demonstrated progressive stenosis with significant increases in high OSI regions in 6 of 11 patient-derived carotid arteries.
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