Key result
In patients with chronic Chagas cardiomyopathy, higher anti-β1 antibody titers were directly associated with an increased rate-pressure product during exercise (rs=0.371, p=0.005).
Why the study?
There are few studies regarding the adaptive role of anti-β1 and anti-M2 antibodies in chronic Chagas cardiomyopathy.
Do anti-β1 and anti-M2 antibody titers correlate with heart rate variability and rate-pressure product in patients with chronic Chagas cardiomyopathy?
Cross-Sectional (n=64)
No
Do anti-β1 and anti-M2 antibody titers correlate with heart rate variability and rate-pressure product in patients with chronic Chagas cardiomyopathy?
In patients with chronic Chagas cardiomyopathy, anti-β1 and anti-M2 antibodies are associated with altered nighttime heart rate variability and rate-pressure product during exercise, suggesting a modulatory effect on the autonomic nervous system.
Answers are grounded in this paper and cite their sources.
May suggest autonomic effects in Chagas cardiomyopathy; hypothesis-generating and should not yet change practice.
No abstract yet. The journal hasn't published one we can show.
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Cunha et al. (2022) conducted a cross-sectional in Chronic Chagas cardiomyopathy (n=64). Anti-β1 and anti-M2 antibodies was evaluated on Correlation between anti-β1 antibody titers and rate-pressure product (RPP) on cardiopulmonary exercise testing (rs=0.371, p=0.005). In patients with chronic Chagas cardiomyopathy, higher anti-β1 antibody titers were directly associated with an increased rate-pressure product during exercise (rs=0.371, p=0.005).
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