Aortic valve stenosis in patients undergoing PCI was associated with a significantly higher risk of all-cause mortality compared to those without AS (HR 3.06; 95% CI 2.41-3.90; p < 0.001).
Observational (n=9,690)
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Does aortic valve stenosis stratified by peak aortic jet velocity predict outcomes in patients undergoing PCI?
Coexisting aortic valve stenosis, assessed by peak aortic jet velocity, is an independent predictor of worse short- and long-term outcomes in patients undergoing PCI.
Hazard Ratio: 3.06 (95% CI 2.41–3.9)
valor p: p=< 0.001
Background: Coronary artery disease (CAD) and aortic valve stenosis (AS) often coexist, with AS exacerbating myocardial ischemia and affecting prognosis. Aims: To investigate the prognostic impact of AS stratified by peak aortic jet velocity (AV-Vel) in patients undergoing PCI. Methods and results: We conducted retrospective multicenter observational study involving patients who underwent percutaneous coronary intervention (PCI) between April 2013 and March 2019. The patients were divided into non-AS group and AS group. The AS group was further categorized: 2.6 ≤ AV-Vel < 3.0 m/s, mild AS; 3.0 ≤ AV-Vel < 4.0 m/s, moderate AS; and AV-Vel ≥ 4.0 m/s, severe AS. The primary outcome was all-cause mortality, and the secondary outcome was major adverse cardiovascular events (MACE), defined as a composite of all-cause mortality, myocardial infarction, or stroke. Multivariable Cox proportional hazards analysis was performed over 5-year observation period, with landmark analyses conducted at 30 days after PCI and from day 31 after PCI to 5 years. In total, 9,690 patients were analyzed (AS group, n = 361). Over a median follow-up of 2.57 (IQR: 0.89-4.24) years, AS group exhibited higher rates of mortality (HR: 3.06; 95% CI: 2.41-3.90; p < 0.001) and MACE (HR: 2.45; 95%CI: 1.97-3.04; p < 0.001) compared with non-AS group. Subgroup analysis revealed that patients with moderate and severe AS had worse short-term mortality and MACE within 30 days after PCI than the non-AS group, while patients with mild to severe AS showed significantly worse long-term outcomes than the non-AS group. Conclusions: AV-Vel is independently associated with both short- and long-term outcomes in patients undergoing PCI.
Iwai et al. (Fri,) conducted a observational in Coronary artery disease and aortic valve stenosis (n=9,690). Aortic valve stenosis (AS) vs. Non-AS group was evaluated on All-cause mortality (HR 3.06, 95% CI 2.41-3.90, p=< 0.001). Aortic valve stenosis in patients undergoing PCI was associated with a significantly higher risk of all-cause mortality compared to those without AS (HR 3.06; 95% CI 2.41-3.90; p < 0.001).