June 27, 2012Physiological ResearchOpen Access

Age-Dependent Salt Hypertension in Dahl Rats: Fifty Years of Research

View Full Paper

Ask AI

Bookmark

Population

Dahl salt-sensitive and salt-resistant rats (preclinical model)

Comparison

Dietary interventions and pharmacological… vs Age-matched controls or different developmental…

Design

Review

Authors

JZJosef ZichaHypertension Canada ZDZ DobešováPalacký University Olomouc MVMartina VokurkováInstitute of Rheumatology

Discussion

Member takes

Implication

Age may dictate preventive intervention efficacy in salt hypertension; leaves open translation to human age-specific strategies.

Structured PICO

Population

Dahl salt-sensitive and salt-resistant rats (preclinical model)

Intervention

Dietary interventions (high salt, potassium, calcium) and pharmacological treatments at different developmental stages

Comparator

Age-matched controls or different developmental stages

Outcome

Development of salt-induced hypertension and organ damagesurrogate

This review highlights that the pathophysiological mechanisms and responses to dietary or pharmacological interventions in salt-sensitive Dahl rats are highly dependent on the age at which the intervention is applied.

Cite This Study

Zicha et al. (2012) studied this question.

synapsesocial.com/papers/6a22283f4ae3d5108796fc7f https://doi.org/10.33549/physiolres.932363

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Age-Dependent Salt Hypertension in Dahl Rats: Fifty Years of Research

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Age-Dependent Salt Hypertension in Dahl Rats: Fifty Years of Research

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider