Key result
In Dahl salt-sensitive rats, a high salt diet gradually impairs renal autoregulatory capacity, with renal morphological injuries developing before the loss of dynamic autoregulation.
Population
Dahl salt-sensitive rats, Dahl salt-resistant rats, spontaneously hypertensive rats, and Sprague-Dawley rats
Comparison
High salt diet (inducing hypertension) vs Low salt diet and normotensive/resistant rat…
Design
Preclinical
Authors
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Impaired renal autoregulation may drive early injury in Dahl S rats; leaves open relevance to human salt-sensitive hypertension.
In Dahl salt-sensitive rats, impaired renal autoregulation is a consequence rather than the cause of the process leading to renal failure.
Karlsen et al. (1997) studied Hypertension and renal injury. High salt diet vs. Low salt diet / other rat strains was evaluated on Dynamic autoregulatory capacity and renal morphological injuries. In Dahl salt-sensitive rats, a high salt diet gradually impairs renal autoregulatory capacity, with renal morphological injuries developing before the loss of dynamic autoregulation.
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