Key result
In dogs with experimental heart failure, coadministration of BNP and furosemide increased GFR and attenuated furosemide-induced aldosterone activation (47 vs 100 ng/dL; P=0.0007) versus furosemide alone.
Why the study?
Does coadministration of BNP and furosemide improve diuresis, natriuresis, and GFR while suppressing aldosterone activation compared to furosemide alone in experimental heart failure?
Does coadministration of BNP and furosemide improve diuresis, natriuresis, and GFR while suppressing aldosterone activation compared to furosemide alone in experimental heart failure?
Absolute Event Rate: 47% vs 100%
p-value: p=0.0007
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Does not support clinical use of BNP with furosemide in HF; extends preclinical data but leaves open human translation.
Cataliotti et al. (2004) studied Congestive heart failure. Furosemide and Brain Natriuretic Peptide (BNP) vs. Furosemide alone was evaluated on Plasma aldosterone (p=0.0007). In dogs with experimental heart failure, coadministration of BNP and furosemide increased GFR and attenuated furosemide-induced aldosterone activation (47 vs 100 ng/dL; P=0.0007) versus furosemide alone.
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