Key result
The presence of the NOS3 gene C-allele significantly elevated the risk of unilateral atherosclerotic plaques on carotid arteries (OR 3.73) in patients with essential arterial hypertension.
Why the study?
The mechanisms orchestrating the balance between nitric oxide and endothelium-derived contracting factors, and genetic predisposition to endothelial dysfunction in hypertensive patients, remain to be determined.
Do NOS3 (rs2070744) and GNB3 (rs5443) gene polymorphisms increase the risk of endothelial dysfunction and carotid intima-media thickness in hypertensive patients?
Case-Control (n=148)
No
Do NOS3 (rs2070744) and GNB3 (rs5443) gene polymorphisms increase the risk of endothelial dysfunction and carotid intima-media thickness in hypertensive patients?
Odds Ratio: 3.73 (95% CI 1.24–11.2)
p-value: p=0.019
NOS3 (rs2070744) C-allele and GNB3 (rs5443) T-allele are associated with an increased risk of endothelial dysfunction and carotid atherosclerosis in hypertensive patients.
Should not yet change hypertension care; hypothesis-generating for NOS3 genotyping in carotid risk stratification.
The mechanisms orchestrating the balance between nitric oxide and endothelium-derived contracting factors, and genetic predisposition to endothelial dysfunction in hypertensive patients remain to be determined. One-hundred hypertensive patients participated in the case-control study to clarify the risk of endothelial dysfunction and carotid "intima media" thickness (IMT) changes depending on NOS3 (rs2070744) and GNB3 (rs5443) genes' polymorphisms. It is found that presence of NOS3 gene's С-allele significantly elevates the risk of atherosclerotic plaques on carotid arteries (OR95%CI: 1.24-11.20; р = 0.019) and the probability of low NOS3 gene expression (OR95%CI: 17.72-520.0; р < 0.001). Homozygous carriage of С-allele of GNB3 gene is protective and corresponds to the lowest chances of the carotid IMT increase, atherosclerotic plaques formation and sVCAM-1 elevation (OR = 0.10-0.34; OR95%CI: 0.03-0.95; р ≤ 0.035-0.001). Vice versa, Т-allele of GNB3 gene significantly augments the risk of the carotid IMT increase (OR95%CI: 1.09-7.74; р = 0.027) including development of atherosclerotic plaques, associating GNB3 (rs5443) with cardiovascular pathology.
No takes yet. Share an insight, caveat, or question.
Sydorchuk et al. (2023) conducted a case-control in Essential arterial hypertension (n=148). NOS3 (rs2070744) C-allele vs. NOS3 TT-genotype was evaluated on Risk of unilateral atherosclerotic plaques on the common carotid artery (OR 3.73, 95% CI 1.24-11.20, p=0.019). The presence of the NOS3 gene C-allele significantly elevated the risk of unilateral atherosclerotic plaques on carotid arteries (OR 3.73) in patients with essential arterial hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: